About the GoKinD Study

The purpose of the Genetics of Kidneys in Diabetes (GoKinD) Study is to establish a repository of DNA and clinical information from adults with long-term Type 1 diabetes, with or without kidney disease, along with their parents. The fundamental aim of GoKinD is to facilitate investigator-driven research into the genetic basis of diabetic kidney disease as well as other issues concerning Type 1 diabetes. This clinically well-characterized population provides a scientific resource maintained under the joint stewardship of JDRF, the Joslin Diabetes Center, GWU and CDC. All collaborating organizations are committed to establishing and maintaining access to the data set as much as is feasible.

The GoKinD collection includes the following:

• DNA from study participants, in predefined sets of Singletons and Trios.
• Plasma, serum, urine samples from study participants
• Clinical data, available in SAS data sets. This will include aggregate summary data for case and control singleton and trios for nephropathy status, clinical characteristics, diabetes characteristics, and related physical, biochemical and complications of diabetes.
• Samples have been genotyped at HLA (DRB1, DQA1, DQB1) and INS loci.

GoKinD Baseline Data Set

Baseline Data Set Description
Baseline Clinical Data Summary

**ACCESS TO THE GOKIND COLLECTION**

We are currently in the process of organizing a permanent repository for the GoKind collection. Until this is complete, applications for access will not be accepted. For more information please contact Helen Nickerson (hnickerson@jdrf.org) or Marie Nierras (cnierras@jdrf.org).

Previous recipients of GoKinD DNA and data are listed below.

Information on the GoKinD collection may also be found at the NIDDK repository web page:

Click Here: NIDDK_GoKIND

Whole Genome Genotyping of the GoKind Collection by GAIN

In 2006, GoKind was selected by the FNIH Genetic Association Information Network (GAIN) program for whole genome genotyping. This is now complete and genotyping and clinical data from GoKind is now publicly available to qualified applicants via the FNIH website: http://www.fnih.org/GAIN2/home_new.shtml

GoKinD Publications

• Genetics of Kidneys in Diabetes (GoKinD) Study: A Genetics Collection Available for Identifying Genetic Susceptibility Factors for Diabetic Nephropathy in Type 1 Diabetes, P.W. Mueller, et. al., J Am Soc Nephrol 17: 1782-1790: 2006.
• GOKIND, Genetics of Kidneys in Diabetes, S. Dylak, Countdown Magazine, Fall 2006.
• High-resolution genotyping lf HLA-DQA1 in the GoKinD study and identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-DQA1*0404, S.K. Cordovado, et. al., Tissue Antigens 2005: 65: 448-458.
• Polymorphism Scan for Differences Between Transmitted and Nontransmitted RDB1*030101 Alleles Outside of Exon 2 for Type 1 Diabetes: The Frequence of Polymorphisms Is Similar, C.N. Greene, et. al., Human Immunology 65, 737-744 (2004).
• High-resolution sequence-based typing strategy for HLA_DQA1 using SSP-PCR and subsequent genotyping analysis with novel spreadsheet program, S.K. Cordovado, et. al., Tissue Antigens 2001: 58: 308-314.

Previous recipients of GoKinD DNA and data collection:

GoKinD Contributing Investigators

Stephen A. Brietzke, University of Missouri
David Brillon, N Y Presbyterian Hospital, Cornell University
George A. Burghen, University of Tennessee
George W. Burke, University of Miami
Patricia Cleary, GWU Biostatistics Center (COC)
Suzanne Cordovado, Centers for Disease Control and Prevention
Debra Counts, University of Maryland Medical System
James Desemone, Albany Medical Center
Steven V. Edelman, University of California San Diego
Carla Greenbaum, Virginia Mason Research Center
Richard A.Guthrie, Mid-America Diabetes Associates, P.A.
Irene Hramiak, St. Joseph's Health Care, Univ. of Western Ontario
Mark Johnson, University of North Carolina (Chapel Hill)
Lois Jovanovic, Sansum Medical Research Center
John I. Malone, University of South Florida
Michael Mauer, University of Minnesota
Michael E. May, Vanderbilt University Medical Center
Larry Melton, Baylor University Medical Center
Mark E. Molitch, Northwestern University
Pat Mueller, Centers for Disease Control and Prevention
Robert E. Ratner, Med-Star Clinical Research Center
John Rogus, Joslin Diabetes Center
William L. Sivitz, University of Iowa
Adam Smiles, Joslin Diabetes Center
Mike Steffes, Dept. of Lab. Medicine & Pathology, U. of Minnesota
Maria Szpiech, Medical University of South Carolina
James Warram, Joslin Diabetes Center
Neil H. White, Washington University School of Medicine
Bernard Zinman, Mount Sinai Hospital, Univ. of Toronto