JDRF is creating a future without type 1 diabetes (T1D) by funding and advocating for breakthrough scientific research. One of our strategies is to help promising scientists establish careers in the field of T1D research. The investigators featured here form the newest group to receive early-career funding from JDRF. Meet the future of T1D research.
A goal of Elad Sintov, Ph.D., is to find a way to transplant beta cells without the use of immunosuppressive treatments.
In a small subpopulation of people living with T1D, transplantation of beta cells can be, literally, a life-saver. Unfortunately, they require long-term immunosuppressive treatments, and most of those beta cells will be gone at two years, rendering these people insulin-dependent again. One avenue to overcome this is to produce the beta cells from stem cells, which have been modified to be immune to a cellular attack. In other words, making insulin-producing beta cells unrecognizable to the immune system. That’s what Elad Sintov, Ph.D., is trying to do, with a JDRF postdoctoral fellowship at Harvard University, sponsored by MilliporeSigma.